Drug interactions
Clonazepam + Selinexor
Severity: Moderate
Clonazepam and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, fatigue and confusion, which may be worsened by sedatives such as clonazepam. The combined effect may raise fall risk and impair cognition.
What this interaction means in plain words
Clonazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and falls and use the lowest effective clonazepam dose. Counsel patients on avoiding driving when symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Clonazepam with Selinexor?
MediHelp rates the interaction as moderate. Clonazepam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, fatigue and confusion, which may be worsened by sedatives such as clonazepam. The combined effect may raise fall risk and impair cognition.
How serious is the interaction between Clonazepam and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls and use the lowest effective clonazepam dose. Counsel patients on avoiding driving when symptomatic.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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