Drug interactions
Clonazepam + Temazepam
Severity: Moderate
Clonazepam and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together causes additive sedation, psychomotor impairment and respiratory depression with little added benefit. Falls and next-day drowsiness are particular risks.
What this interaction means in plain words
Clonazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Avoid duplicate benzodiazepine therapy and consolidate to one agent where possible. If both are needed, use the lowest doses and monitor sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Clonazepam with Temazepam?
MediHelp rates the interaction as moderate. Clonazepam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together causes additive sedation, psychomotor impairment and respiratory depression with little added benefit. Falls and next-day drowsiness are particular risks.
How serious is the interaction between Clonazepam and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate benzodiazepine therapy and consolidate to one agent where possible. If both are needed, use the lowest doses and monitor sedation.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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