Drug interactions
Clonazepam + Ziconotide
Severity: Moderate
Clonazepam and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrathecal ziconotide commonly causes dizziness, confusion and sedation, and in some patients depressed consciousness. Adding clonazepam may intensify these cognitive and sedative effects.
What this interaction means in plain words
Clonazepam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels while clonazepam potentiates GABA-A receptors.
What to do
Monitor mental status and level of consciousness, particularly during ziconotide titration. Reduce or stop the sedating drug or ziconotide if cognitive impairment or sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Clonazepam with Ziconotide?
MediHelp rates the interaction as moderate. Clonazepam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intrathecal ziconotide commonly causes dizziness, confusion and sedation, and in some patients depressed consciousness. Adding clonazepam may intensify these cognitive and sedative effects.
How serious is the interaction between Clonazepam and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of consciousness, particularly during ziconotide titration. Reduce or stop the sedating drug or ziconotide if cognitive impairment or sedation develops.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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