Drug interactions
Clonidine + Insulin degludec-insulin aspart
Severity: Moderate
Clonidine and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine can blunt sympathetic warning symptoms of hypoglycemia and may alter glucose levels in either direction. This can make low blood glucose harder to detect in insulin-treated patients.
What this interaction means in plain words
Clonidine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Central alpha-2 agonism reduces sympathetic outflow, masking adrenergic hypoglycemia symptoms and affecting insulin secretion.
What to do
Monitor blood glucose more often when starting or stopping clonidine and educate the patient about atypical hypoglycemia symptoms. Adjust insulin if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Clonidine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine can blunt sympathetic warning symptoms of hypoglycemia and may alter glucose levels in either direction. This can make low blood glucose harder to detect in insulin-treated patients.
How serious is the interaction between Clonidine and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or stopping clonidine and educate the patient about atypical hypoglycemia symptoms. Adjust insulin if control changes.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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