Drug interactions
Clonidine + Risperidone
Severity: Moderate
Clonidine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone has notable alpha-1 blocking activity and can cause orthostatic hypotension, adding to the effect of clonidine. Sedation, dizziness and falls may increase.
What this interaction means in plain words
Clonidine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive hypotension from central alpha-2 agonism and antipsychotic alpha-1 adrenergic blockade.
What to do
Monitor blood pressure, including standing readings, and sedation when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Clonidine with Risperidone?
MediHelp rates the interaction as moderate. Clonidine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone has notable alpha-1 blocking activity and can cause orthostatic hypotension, adding to the effect of clonidine. Sedation, dizziness and falls may increase.
How serious is the interaction between Clonidine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, and sedation when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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