Drug interactions
Clopidogrel + Etodolac
Severity: Major
Clopidogrel and Etodolac: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair hemostasis and etodolac may cause gastrointestinal mucosal injury, so together they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Clopidogrel and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effect (P2Y12 blockade plus NSAID COX inhibition) with NSAID-induced mucosal damage.
What to do
Avoid unless clearly needed; use paracetamol for analgesia when possible. If combined, add a proton pump inhibitor (avoiding omeprazole/esomeprazole with clopidogrel) and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Etodolac?
MediHelp rates the interaction as major. Clopidogrel and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs impair hemostasis and etodolac may cause gastrointestinal mucosal injury, so together they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Clopidogrel and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly needed; use paracetamol for analgesia when possible. If combined, add a proton pump inhibitor (avoiding omeprazole/esomeprazole with clopidogrel) and monitor for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
