Drug interactions
Clopidogrel + Felodipine
Severity: Minor
Clopidogrel and Felodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is not a recognized CYP2C19 inhibitor, and no meaningful reduction in clopidogrel activation has been established for it. Calcium channel blockers as a class have shown inconsistent signals of reduced platelet inhibition, mostly with CYP3A4-inhibiting agents.
What this interaction means in plain words
Clopidogrel and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Possible minor interference with clopidogrel bioactivation; the mechanism is not established for felodipine.
What to do
No action is generally required. Continue both drugs with routine cardiovascular follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Felodipine?
MediHelp rates the interaction as minor. Clopidogrel and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine is not a recognized CYP2C19 inhibitor, and no meaningful reduction in clopidogrel activation has been established for it. Calcium channel blockers as a class have shown inconsistent signals of reduced platelet inhibition, mostly with CYP3A4-inhibiting agents.
How serious is the interaction between Clopidogrel and Felodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Continue both drugs with routine cardiovascular follow-up.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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