Drug interactions
Clopidogrel + Lapatinib
Severity: Minor
Clopidogrel and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and could reduce formation of clopidogrel's active metabolite, although CYP2C19 is the main activating enzyme and the effect is probably small. Clinical significance is unproven.
What this interaction means in plain words
Clopidogrel and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Lapatinib belongs to Oncology.
Why it happens
Possible CYP3A4 inhibition by lapatinib reducing clopidogrel bioactivation.
What to do
No dose adjustment is needed; monitor for cardiovascular events in patients with high thrombotic risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Clopidogrel with Lapatinib?
MediHelp rates the interaction as minor. Clopidogrel and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and could reduce formation of clopidogrel's active metabolite, although CYP2C19 is the main activating enzyme and the effect is probably small. Clinical significance is unproven.
How serious is the interaction between Clopidogrel and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for cardiovascular events in patients with high thrombotic risk.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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