Drug interactions
Clopidogrel + Oxaprozin
Severity: Major
Clopidogrel and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair hemostasis, and oxaprozin also irritates the gastric mucosa. Used together they raise the risk of gastrointestinal and other bleeding well above that of either drug alone.
What this interaction means in plain words
Clopidogrel and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: clopidogrel blocks P2Y12-mediated platelet aggregation while NSAID inhibition of COX-1 reduces platelet thromboxane and damages gastric mucosa.
What to do
Avoid the combination where possible and use acetaminophen or another alternative for pain. If it must be used, give the shortest course and add gastroprotection with a proton pump inhibitor such as pantoprazole, monitoring for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Oxaprozin?
MediHelp rates the interaction as major. Clopidogrel and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs impair hemostasis, and oxaprozin also irritates the gastric mucosa. Used together they raise the risk of gastrointestinal and other bleeding well above that of either drug alone.
How serious is the interaction between Clopidogrel and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use acetaminophen or another alternative for pain. If it must be used, give the shortest course and add gastroprotection with a proton pump inhibitor such as pantoprazole, monitoring for bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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