Drug interactions
Clopidogrel + Rifapentine
Severity: Moderate
Clopidogrel and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP enzymes, which can increase the conversion of clopidogrel to its active thiol metabolite. This may enhance platelet inhibition and raise the risk of bleeding.
What this interaction means in plain words
Clopidogrel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induction of CYP3A4 and other CYP enzymes increases bioactivation of the clopidogrel prodrug.
What to do
Monitor for signs of bleeding and bruising when rifapentine is started or continued with clopidogrel. Reassess the need for dual therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Clopidogrel with Rifapentine?
MediHelp rates the interaction as moderate. Clopidogrel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP enzymes, which can increase the conversion of clopidogrel to its active thiol metabolite. This may enhance platelet inhibition and raise the risk of bleeding.
How serious is the interaction between Clopidogrel and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and bruising when rifapentine is started or continued with clopidogrel. Reassess the need for dual therapy if bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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