Drug interactions
Clopidogrel + Sertraline
Severity: Moderate
Clopidogrel and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline depletes platelet serotonin and mildly impairs platelet aggregation. Combined with clopidogrel it can increase the risk of bleeding, notably in the gastrointestinal tract.
What this interaction means in plain words
Clopidogrel and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on platelet function from SSRI-induced serotonin depletion plus P2Y12 inhibition.
What to do
Monitor for bleeding and consider gastroprotection in patients at higher GI risk. Weigh benefit of the antidepressant against bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Clopidogrel with Sertraline?
MediHelp rates the interaction as moderate. Clopidogrel and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline depletes platelet serotonin and mildly impairs platelet aggregation. Combined with clopidogrel it can increase the risk of bleeding, notably in the gastrointestinal tract.
How serious is the interaction between Clopidogrel and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in patients at higher GI risk. Weigh benefit of the antidepressant against bleeding risk.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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