Drug interactions
Clopidogrel + Ticagrelor
Severity: Major
Clopidogrel and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit the platelet P2Y12 receptor, so using them together provides no added benefit and increases bleeding risk. Ticagrelor can also compete with clopidogrel's effect, making switching strategies important.
What this interaction means in plain words
Clopidogrel and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Duplicate P2Y12 receptor antagonism with additive antiplatelet effect and bleeding risk.
What to do
Avoid concurrent use of the two P2Y12 inhibitors; when switching, follow guideline-recommended transition protocols including any loading dose. Monitor for bleeding during the transition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clopidogrel
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Clopidogrel with Ticagrelor?
MediHelp rates the interaction as major. Clopidogrel and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit the platelet P2Y12 receptor, so using them together provides no added benefit and increases bleeding risk. Ticagrelor can also compete with clopidogrel's effect, making switching strategies important.
How serious is the interaction between Clopidogrel and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two P2Y12 inhibitors; when switching, follow guideline-recommended transition protocols including any loading dose. Monitor for bleeding during the transition.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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