Drug interactions
Clopidogrel + Tolbutamide
Severity: Minor
Clopidogrel and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel may inhibit CYP2C9 in vitro, which could in theory raise tolbutamide concentrations and enhance its glucose-lowering effect. Clinical studies have not shown a meaningful effect.
What this interaction means in plain words
Clopidogrel and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Theoretical inhibition of CYP2C9-mediated tolbutamide metabolism by clopidogrel.
What to do
No dose adjustment is needed. Monitor blood glucose routinely when starting clopidogrel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Clopidogrel with Tolbutamide?
MediHelp rates the interaction as minor. Clopidogrel and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel may inhibit CYP2C9 in vitro, which could in theory raise tolbutamide concentrations and enhance its glucose-lowering effect. Clinical studies have not shown a meaningful effect.
How serious is the interaction between Clopidogrel and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood glucose routinely when starting clopidogrel.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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