Drug interactions
Clopidogrel + Verapamil
Severity: Moderate
Clopidogrel and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may reduce the formation of clopidogrel's active metabolite, potentially lessening platelet inhibition. The clinical significance on cardiovascular outcomes is uncertain.
What this interaction means in plain words
Clopidogrel and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, which contributes to clopidogrel bioactivation.
What to do
Be aware of possible reduced antiplatelet effect in high-risk patients such as those with recent stenting. Consider an alternative calcium channel blocker or antiplatelet agent if concerned.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Verapamil?
MediHelp rates the interaction as moderate. Clopidogrel and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may reduce the formation of clopidogrel's active metabolite, potentially lessening platelet inhibition. The clinical significance on cardiovascular outcomes is uncertain.
How serious is the interaction between Clopidogrel and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible reduced antiplatelet effect in high-risk patients such as those with recent stenting. Consider an alternative calcium channel blocker or antiplatelet agent if concerned.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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