Drug interactions
Clopidogrel + Vonoprazan
Severity: Minor
Clopidogrel and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is mainly metabolized by CYP3A4 and is not a clinically important CYP2C19 inhibitor, unlike omeprazole. A meaningful reduction of clopidogrel activation is not expected, and vonoprazan can be used for gastroprotection in patients on clopidogrel.
What this interaction means in plain words
Clopidogrel and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; vonoprazan has minimal CYP2C19 inhibition, so suppression of clopidogrel bioactivation is theoretical.
What to do
No adjustment needed; continue both drugs and monitor routinely for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Clopidogrel with Vonoprazan?
MediHelp rates the interaction as minor. Clopidogrel and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is mainly metabolized by CYP3A4 and is not a clinically important CYP2C19 inhibitor, unlike omeprazole. A meaningful reduction of clopidogrel activation is not expected, and vonoprazan can be used for gastroprotection in patients on clopidogrel.
How serious is the interaction between Clopidogrel and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; continue both drugs and monitor routinely for bleeding.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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