Drug interactions
Clopidogrel + Zafirlukast
Severity: Minor
Clopidogrel and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel is a prodrug partly activated by CYP3A4, so inhibition could reduce active metabolite formation. CYP2C19 is the dominant pathway and zafirlukast is only a weak CYP3A4 inhibitor, so any loss of antiplatelet effect is probably small.
What this interaction means in plain words
Clopidogrel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slightly reduce bioactivation of clopidogrel.
What to do
No routine change is needed. Consider the combination if a patient has high thrombotic risk and other reasons for reduced clopidogrel response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Zafirlukast?
MediHelp rates the interaction as minor. Clopidogrel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel is a prodrug partly activated by CYP3A4, so inhibition could reduce active metabolite formation. CYP2C19 is the dominant pathway and zafirlukast is only a weak CYP3A4 inhibitor, so any loss of antiplatelet effect is probably small.
How serious is the interaction between Clopidogrel and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Consider the combination if a patient has high thrombotic risk and other reasons for reduced clopidogrel response.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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