Drug interactions
Clorazepate + Dimenhydrinate
Severity: Moderate
Clorazepate and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine, and combining it with clorazepate increases drowsiness and impairs psychomotor performance. Older adults are at greater risk of confusion and falls.
What this interaction means in plain words
Clorazepate and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1 antagonism with anticholinergic effects.
What to do
Advise patients to avoid driving and alcohol, and use lower doses or a non-sedating alternative where possible, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Clorazepate with Dimenhydrinate?
MediHelp rates the interaction as moderate. Clorazepate and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine, and combining it with clorazepate increases drowsiness and impairs psychomotor performance. Older adults are at greater risk of confusion and falls.
How serious is the interaction between Clorazepate and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and use lower doses or a non-sedating alternative where possible, especially in the elderly.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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