Drug interactions
Clorazepate + Diphenoxylate
Severity: Moderate
Clorazepate and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal that can cause CNS depression when taken in excess. With clorazepate, sedation may be additive, especially in children, older adults, or with overdose.
What this interaction means in plain words
Clorazepate and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid and benzodiazepine activity.
What to do
Keep to recommended diphenoxylate doses and monitor for excessive drowsiness. Advise patients against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Clorazepate with Diphenoxylate?
MediHelp rates the interaction as moderate. Clorazepate and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal that can cause CNS depression when taken in excess. With clorazepate, sedation may be additive, especially in children, older adults, or with overdose.
How serious is the interaction between Clorazepate and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep to recommended diphenoxylate doses and monitor for excessive drowsiness. Advise patients against alcohol and driving.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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