Drug interactions
Clorazepate + Dosulepin
Severity: Moderate
Clorazepate and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant, and with clorazepate it can cause additive drowsiness and psychomotor impairment. In overdose the combination is more dangerous because of added respiratory and CNS depression.
What this interaction means in plain words
Clorazepate and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and tricyclic antihistaminic effects.
What to do
Use the lowest effective doses and monitor sedation, particularly at initiation and in older patients. Limit supply in patients at risk of overdose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Clorazepate with Dosulepin?
MediHelp rates the interaction as moderate. Clorazepate and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant, and with clorazepate it can cause additive drowsiness and psychomotor impairment. In overdose the combination is more dangerous because of added respiratory and CNS depression.
How serious is the interaction between Clorazepate and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, particularly at initiation and in older patients. Limit supply in patients at risk of overdose.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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