Drug interactions
Clorazepate + Ganaxolone
Severity: Moderate
Clorazepate and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedating properties, and combining it with a benzodiazepine increases somnolence and CNS depression. Impaired alertness and psychomotor function may result.
What this interaction means in plain words
Clorazepate and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through positive modulation of GABA-A receptors.
What to do
Monitor for excessive sedation and reduce the dose of one or both agents if somnolence occurs. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Clorazepate with Ganaxolone?
MediHelp rates the interaction as moderate. Clorazepate and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedating properties, and combining it with a benzodiazepine increases somnolence and CNS depression. Impaired alertness and psychomotor function may result.
How serious is the interaction between Clorazepate and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the dose of one or both agents if somnolence occurs. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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