Drug interactions
Clorazepate + Istradefylline
Severity: Minor
Clorazepate and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses raises exposure to CYP3A4 substrates, which may increase the effect of clorazepate's active metabolite and lead to greater sedation. The effect is mainly relevant at the 40 mg/day dose.
What this interaction means in plain words
Clorazepate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 at higher doses, reducing metabolism of benzodiazepine substrates.
What to do
Be aware of increased sedation if the istradefylline dose is 40 mg/day, and consider a lower clorazepate dose if effects are excessive. No action is typically needed at 20 mg/day.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Clorazepate with Istradefylline?
MediHelp rates the interaction as minor. Clorazepate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses raises exposure to CYP3A4 substrates, which may increase the effect of clorazepate's active metabolite and lead to greater sedation. The effect is mainly relevant at the 40 mg/day dose.
How serious is the interaction between Clorazepate and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of increased sedation if the istradefylline dose is 40 mg/day, and consider a lower clorazepate dose if effects are excessive. No action is typically needed at 20 mg/day.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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