Drug interactions
Clorazepate + Larotrectinib
Severity: Minor
Clorazepate and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it could slightly raise clorazepate metabolite exposure. Any effect is likely small, with possible mild added sedation.
What this interaction means in plain words
Clorazepate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition may modestly reduce benzodiazepine clearance.
What to do
No routine adjustment is needed; monitor for increased drowsiness and reduce the clorazepate dose if it appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Clorazepate with Larotrectinib?
MediHelp rates the interaction as minor. Clorazepate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor, so it could slightly raise clorazepate metabolite exposure. Any effect is likely small, with possible mild added sedation.
How serious is the interaction between Clorazepate and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for increased drowsiness and reduce the clorazepate dose if it appears.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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