Drug interactions
Clorazepate + Lorazepam
Severity: Major
Clorazepate and Lorazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together provide duplicate therapy and additive sedation, psychomotor impairment and respiratory depression. The risk of dependence and falls is also increased.
What this interaction means in plain words
Clorazepate and Lorazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation at benzodiazepine binding sites.
What to do
Avoid routine concurrent use of two benzodiazepines; if a transition is needed, taper one while introducing the other and monitor sedation and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Lorazepam
Frequently asked questions
Can I take Clorazepate with Lorazepam?
MediHelp rates the interaction as major. Clorazepate and Lorazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two benzodiazepines taken together provide duplicate therapy and additive sedation, psychomotor impairment and respiratory depression. The risk of dependence and falls is also increased.
How serious is the interaction between Clorazepate and Lorazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two benzodiazepines; if a transition is needed, taper one while introducing the other and monitor sedation and respiration.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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