Drug interactions
Clorazepate + Oxazepam
Severity: Moderate
Clorazepate and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines used together produce additive sedation, psychomotor impairment and respiratory depression, with little added therapeutic benefit. The risks of dependence and falls rise, particularly in older adults.
What this interaction means in plain words
Clorazepate and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Avoid concurrent use of two benzodiazepines unless a deliberate switch or taper is underway. During a transition, monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Clorazepate with Oxazepam?
MediHelp rates the interaction as moderate. Clorazepate and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines used together produce additive sedation, psychomotor impairment and respiratory depression, with little added therapeutic benefit. The risks of dependence and falls rise, particularly in older adults.
How serious is the interaction between Clorazepate and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines unless a deliberate switch or taper is underway. During a transition, monitor for oversedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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