Drug interactions
Clorazepate + Primidone
Severity: Moderate
Clorazepate and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is partly metabolized to phenobarbital, adds to the sedative effects of clorazepate. Its enzyme-inducing action may lower clorazepate exposure and alter seizure control or anxiolytic effect.
What this interaction means in plain words
Clorazepate and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 induction by primidone and its phenobarbital metabolite.
What to do
Monitor for sedation and for reduced benzodiazepine efficacy, and adjust the clorazepate dose according to response. Watch for withdrawal or breakthrough seizures if doses change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Clorazepate with Primidone?
MediHelp rates the interaction as moderate. Clorazepate and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, which is partly metabolized to phenobarbital, adds to the sedative effects of clorazepate. Its enzyme-inducing action may lower clorazepate exposure and alter seizure control or anxiolytic effect.
How serious is the interaction between Clorazepate and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for reduced benzodiazepine efficacy, and adjust the clorazepate dose according to response. Watch for withdrawal or breakthrough seizures if doses change.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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