Drug interactions
Clorazepate + Suvorexant
Severity: Moderate
Clorazepate and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are more likely, particularly in older adults.
What this interaction means in plain words
Clorazepate and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression via orexin receptor antagonism and GABA-A potentiation.
What to do
Use the lowest effective dose of each and consider reducing suvorexant. Warn patients about driving and daytime impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Clorazepate with Suvorexant?
MediHelp rates the interaction as moderate. Clorazepate and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are more likely, particularly in older adults.
How serious is the interaction between Clorazepate and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each and consider reducing suvorexant. Warn patients about driving and daytime impairment.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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