Drug interactions
Clorazepate + Zuranolone
Severity: Major
Clorazepate and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Combined with a benzodiazepine, CNS depression and psychomotor impairment can be greater than with either drug alone.
What this interaction means in plain words
Clorazepate and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression through positive modulation of GABA-A receptors.
What to do
Avoid the combination where possible; if both are needed, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Clorazepate with Zuranolone?
MediHelp rates the interaction as major. Clorazepate and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Combined with a benzodiazepine, CNS depression and psychomotor impairment can be greater than with either drug alone.
How serious is the interaction between Clorazepate and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are needed, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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