Drug interactions
Clotrimazole + Lurbinectedin
Severity: Moderate
Clotrimazole and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clotrimazole may increase lurbinectedin exposure, raising risk of myelosuppression and hepatotoxicity. Lurbinectedin labeling cautions against CYP3A inhibitors.
What this interaction means in plain words
Clotrimazole and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Lurbinectedin belongs to Oncology.
Why it happens
Clotrimazole inhibits CYP3A4, the major route of lurbinectedin clearance.
What to do
Avoid systemic clotrimazole and use an alternative antifungal. If combined, monitor blood counts and liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Clotrimazole with Lurbinectedin?
MediHelp rates the interaction as moderate. Clotrimazole and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase lurbinectedin exposure, raising risk of myelosuppression and hepatotoxicity. Lurbinectedin labeling cautions against CYP3A inhibitors.
How serious is the interaction between Clotrimazole and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic clotrimazole and use an alternative antifungal. If combined, monitor blood counts and liver enzymes.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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