Drug interactions
Clotrimazole + Oliceridine
Severity: Moderate
Clotrimazole and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic clotrimazole may inhibit CYP3A4 and raise oliceridine concentrations. This increases the risk of respiratory depression and excessive sedation. Stopping the inhibitor later may reduce opioid effect.
What this interaction means in plain words
Clotrimazole and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of oliceridine.
What to do
Monitor for respiratory depression and sedation and extend dosing intervals as needed. Reassess the dose if clotrimazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Clotrimazole with Oliceridine?
MediHelp rates the interaction as moderate. Clotrimazole and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole may inhibit CYP3A4 and raise oliceridine concentrations. This increases the risk of respiratory depression and excessive sedation. Stopping the inhibitor later may reduce opioid effect.
How serious is the interaction between Clotrimazole and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and extend dosing intervals as needed. Reassess the dose if clotrimazole is stopped.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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