Drug interactions
Clotrimazole + Sparsentan
Severity: Moderate
Clotrimazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is metabolized mainly by CYP3A4, and systemic azole antifungals can raise its exposure. Higher sparsentan levels may increase hypotension, hyperkalemia, edema and renal effects. Clotrimazole is usually used as a lozenge or topical, so the effect depends on how much is absorbed.
What this interaction means in plain words
Clotrimazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Sparsentan belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated metabolism of sparsentan by clotrimazole, which may increase sparsentan exposure.
What to do
Monitor blood pressure, serum potassium, edema and renal function if clotrimazole is used systemically or for prolonged periods with sparsentan. Reduce sparsentan or stop the azole if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Clotrimazole with Sparsentan?
MediHelp rates the interaction as moderate. Clotrimazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan is metabolized mainly by CYP3A4, and systemic azole antifungals can raise its exposure. Higher sparsentan levels may increase hypotension, hyperkalemia, edema and renal effects. Clotrimazole is usually used as a lozenge or topical, so the effect depends on how much is absorbed.
How serious is the interaction between Clotrimazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, edema and renal function if clotrimazole is used systemically or for prolonged periods with sparsentan. Reduce sparsentan or stop the azole if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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