Drug interactions
Clozapine + Daridorexant
Severity: Moderate
Clozapine and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and combining them may increase next-day drowsiness and impair psychomotor performance and driving. Falls and cognitive impairment are of particular concern in older patients.
What this interaction means in plain words
Clozapine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and clozapine's antihistaminic and other sedative actions.
What to do
Use the lowest effective daridorexant dose and counsel patients about daytime impairment and driving. Reassess the need for the hypnotic if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Clozapine with Daridorexant?
MediHelp rates the interaction as moderate. Clozapine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and combining them may increase next-day drowsiness and impair psychomotor performance and driving. Falls and cognitive impairment are of particular concern in older patients.
How serious is the interaction between Clozapine and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel patients about daytime impairment and driving. Reassess the need for the hypnotic if excessive sedation occurs.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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