Drug interactions
Clozapine + Dasatinib
Severity: Major
Clozapine and Dasatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combining them raises the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Clozapine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check baseline and follow-up ECGs and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Clozapine Viatris 100 mg Orodispersible Tablets - SmPC sections 4.3/4.5 (class statement: medicines known to increase QTc interval; "caution should be exercised when clozapine is prescribed with medicines known to increase QTc interval, or causing electrolyte imbalance.") — electronic medicines compendium (UK SmPC)
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Clozapine with Dasatinib?
MediHelp rates the interaction as major. Clozapine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so combining them raises the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Clozapine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECGs and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with long QT or other QT-prolonging drugs.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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