Drug interactions
Clozapine + Eliglustat
Severity: Moderate
Clozapine and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is a substrate rather than a notable inhibitor of CYP2D6, so a clinically important rise in eliglustat from clozapine is not well established. Both drugs can prolong the QT interval, and eliglustat is itself cautioned in combination with other QT-prolonging drugs.
What this interaction means in plain words
Clozapine and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Possible additive QT prolongation; a pharmacokinetic CYP2D6 interaction is not well established.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during combined use. Be cautious with additional CYP2D6 or CYP3A inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Clozapine with Eliglustat?
MediHelp rates the interaction as moderate. Clozapine and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is a substrate rather than a notable inhibitor of CYP2D6, so a clinically important rise in eliglustat from clozapine is not well established. Both drugs can prolong the QT interval, and eliglustat is itself cautioned in combination with other QT-prolonging drugs.
How serious is the interaction between Clozapine and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during combined use. Be cautious with additional CYP2D6 or CYP3A inhibitors.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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