Drug interactions
Colchicine + Elranatamab
Severity: Moderate
Colchicine and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can transiently suppress CYP enzyme activity, which may increase exposure to CYP3A4 substrates such as colchicine. Higher colchicine levels increase the risk of toxicity.
What this interaction means in plain words
Colchicine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity during cytokine release syndrome reduces colchicine clearance.
What to do
Monitor for colchicine toxicity during step-up dosing and for about two weeks after, and consider holding or reducing colchicine during CRS.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Colchicine with Elranatamab?
MediHelp rates the interaction as moderate. Colchicine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can transiently suppress CYP enzyme activity, which may increase exposure to CYP3A4 substrates such as colchicine. Higher colchicine levels increase the risk of toxicity.
How serious is the interaction between Colchicine and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity during step-up dosing and for about two weeks after, and consider holding or reducing colchicine during CRS.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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