Drug interactions
Clozapine + Etomidate
Severity: Moderate
Clozapine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an anesthetic induction agent, and clozapine adds sedation, hypotension and possible respiratory depression. Prolonged recovery and exaggerated hemodynamic effects can occur. Clozapine's anticholinergic and QT effects may also matter perioperatively.
What this interaction means in plain words
Clozapine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects via GABA-A potentiation and clozapine's receptor antagonism.
What to do
Inform the anesthesia team of clozapine use and titrate etomidate carefully. Monitor blood pressure, ventilation and ECG during and after induction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Clozapine with Etomidate?
MediHelp rates the interaction as moderate. Clozapine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an anesthetic induction agent, and clozapine adds sedation, hypotension and possible respiratory depression. Prolonged recovery and exaggerated hemodynamic effects can occur. Clozapine's anticholinergic and QT effects may also matter perioperatively.
How serious is the interaction between Clozapine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of clozapine use and titrate etomidate carefully. Monitor blood pressure, ventilation and ECG during and after induction.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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