Drug interactions
Clozapine + Etravirine
Severity: Moderate
Clozapine and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4, which contributes to clozapine metabolism, so it may lower clozapine concentrations. The effect on clozapine is probably small since CYP1A2 is the main pathway, but loss of control of psychosis is possible. Etravirine also inhibits CYP2C19 and may have mixed effects.
What this interaction means in plain words
Clozapine and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by etravirine may increase clozapine clearance.
What to do
Monitor psychiatric symptoms and consider a clozapine level when etravirine is started or stopped. Adjust the clozapine dose according to clinical response and level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Clozapine with Etravirine?
MediHelp rates the interaction as moderate. Clozapine and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a modest inducer of CYP3A4, which contributes to clozapine metabolism, so it may lower clozapine concentrations. The effect on clozapine is probably small since CYP1A2 is the main pathway, but loss of control of psychosis is possible. Etravirine also inhibits CYP2C19 and may have mixed effects.
How serious is the interaction between Clozapine and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and consider a clozapine level when etravirine is started or stopped. Adjust the clozapine dose according to clinical response and level.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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