Drug interactions
Clozapine + Flibanserin
Severity: Moderate
Clozapine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and can lower blood pressure, so combined use may cause marked drowsiness, orthostasis and syncope. Serotonergic or neuroleptic malignant syndrome effects are theoretically possible.
What this interaction means in plain words
Clozapine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depressant, hypotensive and serotonergic or dopaminergic receptor effects.
What to do
Monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel about alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Flibanserin?
MediHelp rates the interaction as moderate. Clozapine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and can lower blood pressure, so combined use may cause marked drowsiness, orthostasis and syncope. Serotonergic or neuroleptic malignant syndrome effects are theoretically possible.
How serious is the interaction between Clozapine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel about alcohol and driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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