Drug interactions
clozapine + fluvoxamine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ clozapine → toxicity.
Mechanism of action
Strong CYP1A2 inhibition.
Clinical management
Avoid or reduce dose with level monitoring.
Drug reference
References
Frequently asked questions
Can I take clozapine with fluvoxamine?
The interaction is rated: Major. Marked ↑ clozapine → toxicity.
How serious is the interaction between clozapine and fluvoxamine?
The interaction is rated: Major. Evidence level: High.
How is the interaction between clozapine and fluvoxamine managed?
Avoid or reduce dose with level monitoring.
Why do clozapine and fluvoxamine interact?
Strong CYP1A2 inhibition.
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