Drug interactions
Clozapine + Gilteritinib
Severity: Moderate
Clozapine and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval and clozapine can also affect cardiac repolarization. Combined use may raise the risk of serious ventricular arrhythmias, especially in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Clozapine and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform ECG monitoring at baseline and periodically during therapy, and correct hypokalemia and hypomagnesemia. Reduce or interrupt the QT-prolonging agent if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Clozapine with Gilteritinib?
MediHelp rates the interaction as moderate. Clozapine and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval and clozapine can also affect cardiac repolarization. Combined use may raise the risk of serious ventricular arrhythmias, especially in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Clozapine and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and periodically during therapy, and correct hypokalemia and hypomagnesemia. Reduce or interrupt the QT-prolonging agent if QTc rises significantly.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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