Drug interactions
Clozapine + Granisetron
Severity: Moderate
Clozapine and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and clozapine is also linked to myocarditis and arrhythmias. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Clozapine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QTc prolongation via effects on cardiac repolarization.
What to do
Obtain a baseline ECG and electrolytes and monitor the QTc during co-therapy; consider an alternative antiemetic in patients with significant cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Granisetron?
MediHelp rates the interaction as moderate. Clozapine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and clozapine is also linked to myocarditis and arrhythmias. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Clozapine and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor the QTc during co-therapy; consider an alternative antiemetic in patients with significant cardiac risk.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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