Drug interactions
Clozapine + Iloprost
Severity: Moderate
Clozapine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a vasodilator and clozapine commonly causes orthostatic hypotension. Together they can produce additive blood pressure lowering, with dizziness, syncope or falls.
What this interaction means in plain words
Clozapine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from prostacyclin-mediated vasodilation and clozapine alpha-adrenergic blockade.
What to do
Monitor blood pressure and heart rate, especially when starting or increasing iloprost. Reduce the iloprost dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Clozapine with Iloprost?
MediHelp rates the interaction as moderate. Clozapine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a vasodilator and clozapine commonly causes orthostatic hypotension. Together they can produce additive blood pressure lowering, with dizziness, syncope or falls.
How serious is the interaction between Clozapine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially when starting or increasing iloprost. Reduce the iloprost dose if symptomatic hypotension occurs.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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