Drug interactions
Clozapine + Indacaterol-glycopyrronium
Severity: Moderate
Clozapine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has strong anticholinergic activity and can prolong QT, so combining it with glycopyrronium and indacaterol may add to antimuscarinic and cardiac effects. Constipation, which can progress to serious bowel hypomotility, and tachycardia are of particular concern.
What this interaction means in plain words
Clozapine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT or adrenergic cardiac effects.
What to do
Monitor bowel function and heart rate, and obtain an ECG in patients with QT risk factors. Treat constipation promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Clozapine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has strong anticholinergic activity and can prolong QT, so combining it with glycopyrronium and indacaterol may add to antimuscarinic and cardiac effects. Constipation, which can progress to serious bowel hypomotility, and tachycardia are of particular concern.
How serious is the interaction between Clozapine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and heart rate, and obtain an ECG in patients with QT risk factors. Treat constipation promptly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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