Drug interactions
Clozapine + Insulin glargine
Severity: Moderate
Clozapine and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is associated with hyperglycemia, weight gain and insulin resistance, which can undermine glycemic control in insulin-treated patients. Higher insulin doses may be needed during clozapine therapy.
What this interaction means in plain words
Clozapine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Insulin glargine belongs to Endocrine.
Why it happens
Clozapine-induced insulin resistance and metabolic effects antagonize the glucose-lowering effect of insulin.
What to do
Monitor blood glucose and HbA1c regularly and titrate insulin glargine to need. Reassess dose when clozapine is stopped or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Clozapine with Insulin glargine?
MediHelp rates the interaction as moderate. Clozapine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is associated with hyperglycemia, weight gain and insulin resistance, which can undermine glycemic control in insulin-treated patients. Higher insulin doses may be needed during clozapine therapy.
How serious is the interaction between Clozapine and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and titrate insulin glargine to need. Reassess dose when clozapine is stopped or reduced.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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