Drug interactions
Clozapine + Letermovir
Severity: Minor
Clozapine and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A and may modestly raise clozapine exposure, though letermovir can also induce CYP2C19 and CYP2C9. Clozapine is mainly metabolized by CYP1A2, so the effect is uncertain.
What this interaction means in plain words
Clozapine and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Possible CYP3A4 inhibition by letermovir reducing clozapine clearance; magnitude not well established.
What to do
Monitor for clozapine adverse effects such as sedation and hypotension, and check clozapine levels if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Clozapine with Letermovir?
MediHelp rates the interaction as minor. Clozapine and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits CYP3A and may modestly raise clozapine exposure, though letermovir can also induce CYP2C19 and CYP2C9. Clozapine is mainly metabolized by CYP1A2, so the effect is uncertain.
How serious is the interaction between Clozapine and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine adverse effects such as sedation and hypotension, and check clozapine levels if toxicity is suspected.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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