Drug interactions
Clozapine + Liraglutide
Severity: Moderate
Clozapine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can cause hyperglycemia and weight gain that oppose the glucose-lowering effect of liraglutide. Both drugs slow gastrointestinal motility, and clozapine-related constipation or ileus may be worsened.
What this interaction means in plain words
Clozapine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Liraglutide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through clozapine-induced insulin resistance; additive reduction in gut motility.
What to do
Monitor glucose and HbA1c and adjust antidiabetic therapy as needed. Monitor bowel function and treat constipation early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Clozapine with Liraglutide?
MediHelp rates the interaction as moderate. Clozapine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can cause hyperglycemia and weight gain that oppose the glucose-lowering effect of liraglutide. Both drugs slow gastrointestinal motility, and clozapine-related constipation or ileus may be worsened.
How serious is the interaction between Clozapine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and adjust antidiabetic therapy as needed. Monitor bowel function and treat constipation early.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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