Drug interactions
Clozapine + Macimorelin
Severity: Moderate
Clozapine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation, and clozapine also lengthens QT, so the combination may increase the risk of torsades de pointes during the diagnostic test. Macimorelin is given as a single test dose, which limits exposure.
What this interaction means in plain words
Clozapine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive QTc prolongation.
What to do
Where feasible, use an alternative growth hormone stimulation test or defer testing until QT-prolonging drugs are withheld. If testing proceeds, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Clozapine with Macimorelin?
MediHelp rates the interaction as moderate. Clozapine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small QT prolongation, and clozapine also lengthens QT, so the combination may increase the risk of torsades de pointes during the diagnostic test. Macimorelin is given as a single test dose, which limits exposure.
How serious is the interaction between Clozapine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, use an alternative growth hormone stimulation test or defer testing until QT-prolonging drugs are withheld. If testing proceeds, obtain an ECG and correct electrolytes.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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