Drug interactions
Clozapine + Nabilone
Severity: Moderate
Clozapine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is highly sedating and can cause orthostatic hypotension, tachycardia and respiratory effects. Adding nabilone may intensify sedation, dizziness and tachycardia.
What this interaction means in plain words
Clozapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and cardiovascular effects through pharmacodynamic synergy.
What to do
Introduce nabilone at a low dose and monitor sedation, heart rate and blood pressure. Counsel patients about fall risk and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Nabilone?
MediHelp rates the interaction as moderate. Clozapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is highly sedating and can cause orthostatic hypotension, tachycardia and respiratory effects. Adding nabilone may intensify sedation, dizziness and tachycardia.
How serious is the interaction between Clozapine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce nabilone at a low dose and monitor sedation, heart rate and blood pressure. Counsel patients about fall risk and avoid alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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