Drug interactions
Clozapine + Osilodrostat
Severity: Moderate
Clozapine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and clozapine is also associated with QTc prolongation and torsades risk. Combined use may increase the likelihood of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Clozapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization (QT prolongation).
What to do
Obtain a baseline ECG and repeat after initiation or dose change, and correct potassium and magnesium abnormalities. Reconsider the combination if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Clozapine with Osilodrostat?
MediHelp rates the interaction as moderate. Clozapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and clozapine is also associated with QTc prolongation and torsades risk. Combined use may increase the likelihood of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Clozapine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after initiation or dose change, and correct potassium and magnesium abnormalities. Reconsider the combination if QTc becomes markedly prolonged.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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