Drug interactions
Clozapine + Paliperidone
Severity: Moderate
Clozapine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics can prolong the QT interval, and combined use may add to arrhythmic risk. Additive sedation and orthostatic hypotension can also occur.
What this interaction means in plain words
Clozapine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive receptor-blocking effects.
What to do
Obtain an ECG and correct electrolytes if the combination is used. Monitor for orthostasis and sedation and avoid unnecessary antipsychotic polypharmacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Clozapine with Paliperidone?
MediHelp rates the interaction as moderate. Clozapine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antipsychotics can prolong the QT interval, and combined use may add to arrhythmic risk. Additive sedation and orthostatic hypotension can also occur.
How serious is the interaction between Clozapine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes if the combination is used. Monitor for orthostasis and sedation and avoid unnecessary antipsychotic polypharmacy.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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