Drug interactions
Clozapine + Ritlecitinib
Severity: Moderate
Clozapine and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2, the main enzyme clearing clozapine, so clozapine levels may rise. Higher exposure can cause sedation, hypotension, seizures and other dose-related toxicity.
What this interaction means in plain words
Clozapine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Ritlecitinib belongs to Oncology.
Why it happens
CYP1A2 inhibition by ritlecitinib reduces clozapine clearance.
What to do
Monitor for clozapine adverse effects and consider checking clozapine plasma levels after ritlecitinib is started. Reduce the clozapine dose if levels or toxicity increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Clozapine with Ritlecitinib?
MediHelp rates the interaction as moderate. Clozapine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2, the main enzyme clearing clozapine, so clozapine levels may rise. Higher exposure can cause sedation, hypotension, seizures and other dose-related toxicity.
How serious is the interaction between Clozapine and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine adverse effects and consider checking clozapine plasma levels after ritlecitinib is started. Reduce the clozapine dose if levels or toxicity increase.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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